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Human cytomegalovirus infection triggers a paracrine senescence loop in renal epithelial cells

Human cytomegalovirus infection triggers a paracrine senescence loop in renal epithelial cells https://ift.tt/lutUiFS Human cytomegalovirus infection triggers a paracrine senescence loop in renal epithelial cells A senescence-like program is intriguingly transmitted to nearby cells when HCMV infection occurs in renal proximal tubular epithelial cells, which are naturally vulnerable to infection in vivo. This suggests a cytokine (IL-6 mainly)-driven paracrine mechanism of disease amplification.

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