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Catalytic Enantioselective Reductive Alkynylation of Amides Enables One-Pot Syntheses of Pyrrolidine, Piperidine and Indolizidine Alkaloids

Catalytic Enantioselective Reductive Alkynylation of Amides Enables One-Pot Syntheses of Pyrrolidine, Piperidine and Indolizidine Alkaloids https://ift.tt/OzYhEs1 Catalytic Enantioselective Reductive Alkynylation of Amides Enables One-Pot Syntheses of Pyrrolidine, Piperidine and Indolizidine Alkaloids Efficiency, selectivity, and generality are important for total synthesis of natural products , medicines and materials. we present a unified strategy for a one-pot, catalytic enantioselective synthesis of 8 alkaloids and an anticancer antipode using readily available amides and alkynes.

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