Aspirin
Aspirin is a drug that is very
commonly used globally to treat many conditions, and falls under the category
of non-steroidal anti-inflammatory drugs (NSAIDs), as it was the first type
discovered in this group, and aspirin contains the active substance known as
acetylsalicylic acid).
Preparation of aspirin
Aspirin is prepared industrially
in laboratory by the reaction of salicyclic acid with organic acid, which is anhydrous
aceticacid to produce the corresponding ester, , which is acetylsalicylic acid,
which is known commercial- ly as aspirin.
Aspirin uses
Aspirin is usually dispensed
without a prescription, but sometimes a doctor must be consulted and a
prescription used to dispense it, especially in cases that require high doses
of it, such as cases of pain relief. between them, and to determine the
appropriate dose and time to take it.
Warnings before using aspirin
The doctor determines whether or
not to use aspirin, but it is forbidden to take it in case of allergy to it or
one of its components, but caution is advised when using it in the following
cases:
1. If the person is at risk of bleeding.
2. Suffering from asthma.
3. Suffering from stomach or duodenal ulcers.
4. Kidney or liver failure.
5. severe heart failure;
How to store aspirin
The commitment to store and store
the medicine in the correct way reduces the chance of its exposure to damage,
and the most important criteria for storing aspirin medicine include the
following:
1. Store it in places away from moisture.
2. Store it at room temperature, which ranges between 20
- 25°C.
3. Keep it in the box it came in, close it after you have
finished using it, and put it in a place out of the reach of children.
Aspirin drug interactions
The patient should inform the
doctor of all medications, herbal supplements, vitamins, foods and beverages
that he takes, as taking aspirin can interfere with one of them, and therefore
this may require changing the timing of some doses or placing the patient under
observation to assess side effects and their severity. Possible drug
interactions include the following:
1. ACE inhibitors, such as captopril and enalapril.
2. Non-steroidal anti-inflammatory drugs, such as
naproxen and ibuprofen.
3. methotrexate;
4. Anticoagulants, such as heparin and warfarin.
5. Blood sugar lowering drugs.
6. diuretics;
7. phenytoin;
8. Valproic acid.
9. Gout medications, such as probenecid and
sulfinpyrazone.
References
1. K. J. Denniston c J. J.Topping c and R. L.Caretc
“General Organic and Biochemistry”c Mc-Graw- Hillc New York
(2004).
2. K.W. Whittenc R.E. Davis and L. M. Peckc “General Chemistry” 7th ed.
Holt Rinehart and Winstonc New York (2010).
3. Clayden, J.; Greeves, N. and Warren, S. (2012) Organic
Chemistry. Oxford University Press. pp. 1–15. ISBN 0-19-927029-5.
4. Streitwieser, Andrew; Heathcock, Clayton H.; Kosower,
Edward M. (2017). Introduction to Organic Chemistry. New Delhipages=3–4:
Medtech (Scientific International, reprint of revised 4th edition, Macmillan,
1998). ISBN 978-93-85998-89-8.
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