Preparation of aspirin

Aspirin

Aspirin is a drug that is very commonly used globally to treat many conditions, and falls under the category of non-steroidal anti-inflammatory drugs (NSAIDs), as it was the first type discovered in this group, and aspirin contains the active substance known as acetylsalicylic acid).

Preparation of aspirin

Aspirin is prepared industrially in laboratory by the reaction of salicyclic acid with organic acid, which is anhydrous aceticacid to produce the corresponding ester, , which is acetylsalicylic acid, which is known commercial- ly as aspirin.

Aspirin uses

Aspirin is usually dispensed without a prescription, but sometimes a doctor must be consulted and a prescription used to dispense it, especially in cases that require high doses of it, such as cases of pain relief. between them, and to determine the appropriate dose and time to take it.

Warnings before using aspirin

The doctor determines whether or not to use aspirin, but it is forbidden to take it in case of allergy to it or one of its components, but caution is advised when using it in the following cases:

1.      If the person is at risk of bleeding.

2.     Suffering from asthma.

3.     Suffering from stomach or duodenal ulcers.

4.     Kidney or liver failure.

5.     severe heart failure;

How to store aspirin

The commitment to store and store the medicine in the correct way reduces the chance of its exposure to damage, and the most important criteria for storing aspirin medicine include the following:

1.      Store it in places away from moisture.

2.     Store it at room temperature, which ranges between 20 - 25°C.

3.     Keep it in the box it came in, close it after you have finished using it, and put it in a place out of the reach of children.

Aspirin drug interactions

The patient should inform the doctor of all medications, herbal supplements, vitamins, foods and beverages that he takes, as taking aspirin can interfere with one of them, and therefore this may require changing the timing of some doses or placing the patient under observation to assess side effects and their severity. Possible drug interactions include the following:

1.      ACE inhibitors, such as captopril and enalapril.

2.     Non-steroidal anti-inflammatory drugs, such as naproxen and ibuprofen.

3.     methotrexate;

4.     Anticoagulants, such as heparin and warfarin.

5.     Blood sugar lowering drugs.

6.     diuretics;

7.      phenytoin;

8.     Valproic acid.

9.     Gout medications, such as probenecid and sulfinpyrazone.

References

1.      K. J. Denniston c J. J.Topping c and R. L.Caretc “General Organic and Biochemistry”c Mc-Graw- Hillc New York   (2004).

2.     K.W. Whittenc R.E. Davis  and L. M. Peckc “General Chemistry” 7th ed. Holt Rinehart and Winstonc New York (2010).

3.     Clayden, J.; Greeves, N. and Warren, S. (2012) Organic Chemistry. Oxford University Press. pp. 1–15. ISBN 0-19-927029-5.

4.     Streitwieser, Andrew; Heathcock, Clayton H.; Kosower, Edward M. (2017). Introduction to Organic Chemistry. New Delhipages=3–4: Medtech (Scientific International, reprint of revised 4th edition, Macmillan, 1998). ISBN 978-93-85998-89-8.